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Computer-aided detection is used by increasing numbers of radiologists as “a second pair of eyes” when reading mammograms. Radiologists review a mammogram then activate the CAD software and re-evaluate the marked area(s) before issuing a final report. Clinical trials demonstrated that use of the ImageChecker system can result in earlier detection of up to 23.4% of cancers currently detected with screening mammography in those women who had a prior screening mammogram nine to 24 months earlier. CAD has received broad support from radiologists, the American College of Radiology, Medicare, and patient advocacy groups. The American Cancer Society has recognized the benefits of CAD as a technology for breast cancer screening in women of average risk. Recently updated guidelines state: “…CAD systems may aid the average radiologist by substantially improving detection of early stage malignancies with no more than a proportionate increase in recall rate.”